PTEN Hamartoma Tumor Syndrome (PHTS) comprises a group of clinical disorders characterized by genetic alterations in the PTEN gene. Such clinical disorders include Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), and Proteus and Proteus-like syndrome (PS). PHTS is hereditary, and the risk of developing certain features associated with PHTS can be passed from generation to generation in a family.